BACKGROUND With the surge of intervention research examining ways of supporting students with autism spectrum disorder (ASD) in inclusive settings, there remains a need to examine how technology supports could enhance students' learning by offering one size fits one instruction. Furthermore, intervention studies focused on teaching students with ASD how to solve fractions are scarce. AIMS The purpose of this research study was to examine the effects of providing instruction via video modeling (VM), concrete manipulatives, a self-monitoring checklist, and practice for comprehension check on the accuracy of fraction problem solving of three middle school students with ASD. METHODS AND PROCEDURES Through the use of single-case multiple probe across students experimental design, we examined whether a functional relation existed between the intervention and students' improved accuracy of solving simple proper fraction problems. OUTCOMES AND RESULTS All three students improved the accuracy of solving simple proper fraction problems from baseline to intervention sessions and two students generalized the skill to solving whole proper fraction problems. CONCLUSIONS AND IMPLICATIONS The intervention consisting of VM and concrete manipulatives along with additional behavioral strategies offers an option for teachers to accommodate diverse learning needs of students with ASD in a variety of settings. BACKGROUND Children with sensory processing challenges often demonstrate a specific vestibular dysfunction characterized by an irrational fear of movement experiences referred to as gravitational insecurity. PROCEDURES/OUTCOMES This descriptive, exploratory study of existing de-identified data examined characteristics and prevalence of symptoms indicative of gravitational insecurity and the relationship among gravitational insecurity, gender, age, and other types of sensory-motor problems in 689 children, aged 4-12 years, with Sensory Processing Disorder (SPD) and related parent-reported co-morbid diagnoses of Attention Deficit-Hyperactivity Disorder, Anxiety Disorder, Learning Disabilities and Autism Spectrum Disorder. Gravitational insecurity was identified by the sum of eight items on a parent-report clinical questionnaire of sensory processing and motor skills in children. RESULTS/CONCLUSIONS The number and patterns of gravitational insecurity symptoms were not significantly different across age, gender or comorbid diagnoses. Prevalence of symptoms of gravitational insecurity in a clinical population of children with SPD was 15 - 21%. Cluster analysis found two groups with and without gravitational insecurity. In the gravitational insecurity group all eight items examined occurred "sometimes/often" and four or more symptoms were reported by individuals in this group. IMPLICATIONS Gravitational insecurity is an important vestibular-based dysfunction to identify and treat in children with SPD. Future studies should examine the relationship between these symptoms and objective measures of gravitational insecurity. OBJECTIVE To review and describe available pharmacotherapy interventions for smoking cessation during pregnancy&nbsp; nicotine replacement therapy (NRT) and non nicotine replacement therapy. METHODS The PubMed, Medline, and Cochrane databases (1/01/2003 au 5/04/2019) were accessed to identify relevant studies, using the search terms&nbsp;?&nbsp;Tobacco Use Cessation Devices", "nicotine replacement product or therapy", "smoking cessation", "Pregnancy", "pregnant women", "varenicline", "bupropion". Résults There is no data on the impact of NRT on the rate of smoking cessation during pre conception period. According to randomised studies versus placebo, the prescription of NRT during pregnancy (16-hours patches and gums being mainly studied) is not associated with smoking cessation during pregnancy or at the end of pregnancy (LE1). Based on the analysis of all available studies, the prescription of NRT during pregnancy is associated with smoking cessation during pregnancy and at the end of pregnancy (LE2). Co-administration ofient data and low level of evidence to assess the impact of bupropion during the three trimesters of pregnancy, and in particular the neonatal consequences. Because of its amphetamine properties, bupoprion is not recommended for smoking cessation assistance in pregnant women (GRADE C). The available data are very inadequate and low level of evidence to assess the impact of varenicline during pregnancy. For this reason, varenicline cannot be recommended for smoking cessation during pregnancy (professional consensus). CONCLUSIONS The prescription of NRT may be offered to any pregnant woman who has failed a spontaneous smoking cessation without NRT, taking into account the lower risks of premature birth in the case of NRT (GRADE B). https://www.selleckchem.com/MEK.html This prescription can be initiated by the professional taking care of the pregnant woman in early pregnancy (Professional consensus). Smoking during pregnancy is a public health problem. Individual screening is carried out in France during pregnancy consultations, followed by non-systemic care (with or without nicotine replacement therapy). In the UK, pregnant smokers are routinely screened during pregnancy follow-up and then referred to smoking cessation services. In order to improve their adherence, and smoking cessation, patients can be contacted, in particular by phone. We therefore recommend to systematically screen for smoking during pregnancy by asking the question of smoking or by measuring the CO exhaled during the various consultations, to offer care in collaboration with a local smoking cessation service and renew the requests if necessary. We need to develop these care networks in France. Nicotine is the main addictive substance in tobacco and its addictive effects mainly involve dopamine. Nicotine is mainly metabolized (C-oxidation) in the liver to cotinine by the cytochrome P450 enzyme system. Nicotine half-life is short being about 2 hours.Nicotine metabolism appears to be increased during pregnancy, mainly due to an increased cytochrome activity and maternal cardiac output. Thus, the smoking behavior of the pregnant woman is subsequently modified with an increase in withdrawal syndromes and an increased desire to smoke. These pharmacological elements should be taken into account when prescribing nicotine replacement therapy.Regarding the markers of tobacco intoxication, there is a good correlation between the importance of smoking and the measurement of expired air carbon monoxide. Although there is no evidence of decreased obstetrical complications related to its use, it is simple and non-invasive and therefore may be useful in routine practice. It gives an instantaneous value of tobacco intoxication, and represents a starting point for dialogue and management and can help to highlight the reality of withdrawal.